α-Ketoisovaleric acid

Names

[ CAS No. ]:
759-05-7

[ Name ]:
α-Ketoisovaleric acid

[Synonym ]:
a-keto-Isovaleric acid
Dimethylpyruvic acid
α-Oxo-β-methylbutyric acid
Butanoic acid, 3-methyl-2-oxo-
2-Ketoisovaleric acid
KETOVALINE
2-Oxo-3-methylbutyric acid
3-Methyl-2-oxo-butanoic Acid
Isopropylglyoxylic acid
a-Oxo-b-methylbutyric acid
a-keto-b-Methylbutyric acid
α-keto-β-Methylbutyric acid
a-Oxoisovaleric acid
3-methyl-2-oxo-Butyric acid
α-Oxoisovaleric acid
2-Oxo-3-methylbutanoic acid
3-Methyl-2-oxobutanoic acid

Biological Activity

[Description]:

3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) is a precursor of pantothenic acid in Escherichia coli[1]. 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) enhances alpha-ketoisocaproic acid and alpha-keto-beta-methyl-n-valeric acid, but diminishes the corresponding amino acids, and causes an early decline of ornithine along with a late augmentation of plasma arginine[2].

[In Vivo]

3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) induces convulsions through GABAergic and glutamatergic mechanisms in rats[3].

[References]

[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
170.2±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₈O₃

[ Molecular Weight ]:
116.115

[ Flash Point ]:
71.0±15.2 °C

[ Exact Mass ]:
116.047340

[ PSA ]:
54.37000

[ LogP ]:
-0.36

[ Vapour Pressure ]:
0.7±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.432

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2918300090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%