2-Ketoglutaric acid

Names

[ CAS No. ]:
328-50-7

[ Name ]:
2-Ketoglutaric acid

[Synonym ]:
2-oxopentanedionic acid
ketoglutaric acid
EINECS 206-330-3
α-Oxoglutaric acid
FEMA 3891
Pentanedioic acid, 2-oxo- (9CI)
α-Oxopentanedioic acid
α-Ketoglutaric acid
A-KETOGLUTARIC ACID
2-Oxo-Glutaric Acid
2-Oxoglutaric acid,2-Oxopentanedioic acid
2-Oxoglutaric Acid
MFCD00004165
OXOGLUTARIC ACID
KETO-GLU
Pentanedioic acid, 2-oxo-
2-Ketoglutaric acid
2-Oxopentanedioic acid
Glutaric acid, 2-oxo- (8CI)
α-keto-Glutaric acid
Glutaric acid, 2-oxo-
2-Oxo-1,5-pentanedioic acid
Alphaketoglutaric acid

Biological Activity

[Description]:

2-Ketoglutaric acid is an intermediate compound of the Krebs cycle and is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Rocchiccioli F, et al. Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics. Biomed Mass Spectrom. 1984 Jan;11(1):24-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
345.6±25.0 °C at 760 mmHg

[ Melting Point ]:
113-115 °C

[ Molecular Formula ]:
C₅H₆O₅

[ Molecular Weight ]:
146.098

[ Flash Point ]:
177.0±19.7 °C

[ Exact Mass ]:
146.021530

[ PSA ]:
91.67000

[ LogP ]:
-1.43

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.494

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi,T

[ Risk Phrases ]:
R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29183000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

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J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

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