1-Methyluric acid

Names

[ CAS No. ]:
708-79-2

[ Name ]:
1-Methyluric acid

[Synonym ]:
1-methyl-8-oxyxanthine
1-Methyluric acid
1-Methylurate
1MUA
1-methyl-7,9-dihydro-3H-purine-2,6,8-trione
1-Methyl-2,6,8-trihydroxypurine
1-Methyl-harnsaeure

Biological Activity

[Description]:

1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vivo]

Perfusion of the urinary bladder with 1-Methyl uric acid solution shows an increase in the serum total cholesterol level, true triglyceride level, glucose level and insulin level on comparison with perfusion of the urinary bladder with distilled water[1].

[Animal admin]

Rats[1] Adult albino rats of Wistar strain of either sex weighing 200-300 g rats are used for the present study. Thirty albino rats are divided into three groups of ten each. Group I serves as the control group perfused with distilled water. Following cannulation, the bladder is perfused with distilled water. Group II serves as the uric acid perfused group. Group III serves as the 1-Methyl uric acid perfused group. The animals of this group are treated in a similar way as those of control group (Group I) except that the bladder is perfused with the aqueous solution of 1-Methyl uric acid (0.0024 g/100 mL) instead of distilled water[1].

[References]

[1]. Balasubramanian T, et al. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003 Oct 5;3:930-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.73g/cm3

[ Boiling Point ]:
315.51°C (rough estimate)

[ Melting Point ]:
>325ºC

[ Molecular Formula ]:
C₆H₆N₄O₃

[ Molecular Weight ]:
182.13700

[ Exact Mass ]:
182.04400

[ PSA ]:
103.51000

[ Index of Refraction ]:
1.695

[ Storage condition ]:
Refrigerator

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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