2-Hydroxyphenylacetic acid

Names

[ CAS No. ]:
614-75-5

[ Name ]:
2-Hydroxyphenylacetic acid

[Synonym ]:
Hydroxyphenylacetic acid
a-Hydroxy-a-toluic Acid
A-HYDROXYPHENYLACETIC ACID
Mandelic acid
2-hydroxy-2-phenylacetic acid
(±)-a-Hydroxyphenylacetic Acid
EINECS 210-393-2
benzeneacetic acid, a-hydroxy-
2-Hydroxy-2-phenylethanoic acid
Benzeneacetic acid, α-hydroxy-
(±)-2-Hydroxy-2-phenylethanoic Acid
DL-mandelic acid
2-Hydroxyphenylacetic acid
Hydroxy(phenyl)acetic acid
a-Hydroxybenzeneacetic Acid
MFCD00004323
(±)-a-Hydroxybenzeneacetic Acid
2-Hydroxyphenylaceticacid

Biological Activity

[Description]:

2-Hydroxyphenylacetic acid is a potential biomarker for the food products, and found to be associated with phenylketonuria (PKU).

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Mönch E, et al. Examination of urine metabolites in the newborn period and during protein loading tests at 6 months of age--Part 1. Eur J Pediatr. 1990;149 Suppl 1:S17-24.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
321.8±22.0 °C at 760 mmHg

[ Melting Point ]:
145-147 °C(lit.)

[ Molecular Formula ]:
C₈H₈O₃

[ Molecular Weight ]:
152.147

[ Flash Point ]:
162.6±18.8 °C

[ Exact Mass ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29182990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway.

J. Biol. Chem. 273(40) , 25974-86, (1998)

The paa cluster of Escherichia coli W involved in the aerobic catabolism of phenylacetic acid (PA) has been cloned and sequenced. It was shown to map at min 31.0 of the chromosome at the right end of ...

Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco.

Food Chem. Toxicol. 41(2) , 247-58, (2003)

Indian-made bidi cigarettes sold in the United States are available in a variety of exotic (e.g. clove, mango) and candy-like (e.g. chocolate, raspberry) flavors. Because certain tobacco flavorings co...