5-Hydroxydopamine hydrochloride

Names

[ Name ]:
5-Hydroxydopamine hydrochloride

[Synonym ]:
MFCD00012899
5-Hydroxydopamine hydrochloride
EINECS 227-223-8
3,4,5-Trihydroxyphenethylamine
Pyrogallol,hydrochloride

Biological Activity

[Description]:

5-Hydroxydopamine is a naturally occurring amine in human urine.

[Related Catalog]:

Research Areas >> Others

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Abe K, et al. The effects of 5-hydroxydopamine on salivary flow rates and protein secretion by the submandibular and parotid glands of rats. Exp Physiol. 1996 Jul;81(4):645-53.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.395 g/cm3

[ Boiling Point ]:
414.5ºC at 760 mmHg

[ Melting Point ]:
218-220ºC(lit.)

[ Molecular Formula ]:
C₈H₁₂ClNO₃

[ Molecular Weight ]:
205.63900

[ Flash Point ]:
204.5ºC

[ Exact Mass ]:
205.05100

[ PSA ]:
86.71000

[ LogP ]:
1.80690

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A microdialysis study on striatal dopamine, 5-HT and metabolites in conscious rats after various treatments: evidence for extravesicular release of dopamine.

Neuroreport 5(1) , 53-6, (1993)

The effects of death and various treatments that affect the status of nigrostriatal neurones on striatal release of dopamine (DA) and 5-hydroxytryptamine (5-HT) and their metabolites 3,4-dihydroxyphen...

Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes.

Exp. Neurol. 115(2) , 193-9, (1992)

We have developed and characterized dopamine-containing liposomes which exhibited in vitro sustained release of dopamine for over 40 days. These liposomes were stereotactically implanted into the part...

Uptake of 5-hydroxydopamine into non-sympathetic nerves of guinea-pig uterine artery in late pregnancy.

J. Neurocytol. 22(3) , 164-75, (1993)

Perivascular nerve fibres of the uterine artery of virgin and late pregnant guinea-pigs were examined under the electron microscope following loading with 5-hydroxydopamine, a marker for catecholamine...

Related Compounds

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