Oxidopamine hydrochloride

Names

[ Name ]:
Oxidopamine hydrochloride

[Synonym ]:
6-Hydroxydopamine hydrochloride
6-HYDROXYDOPAMINE HYDROCHLORIDE
5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride
Oxidopamine (hydrochloride)

Biological Activity

[Description]:

Oxidopamine hydrochloride is a neurotoxic synthetic organic compound, selectively destroys dopaminergic and noradrenergic neurons in the brain.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
406ºC at 760 mmHg

[ Melting Point ]:
232-233ºC (dec.)(lit.)

[ Molecular Formula ]:
C₈H₁₂ClNO₃

[ Molecular Weight ]:
205.63900

[ Flash Point ]:
199.3ºC

[ Exact Mass ]:
205.05100

[ PSA ]:
86.71000

[ LogP ]:
1.80690

[ Vapour Pressure ]:
3.58E-07mmHg at 25°C

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC4650000

CHEMICAL NAME :: 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 28094-15-7

LAST UPDATED :: 199609

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :: 205.66

WISWESSER LINE NOTATION :: Z2R BQ CQ DQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,411,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
DC4650000

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