SKF38393 HCl

Names

[ Name ]:
SKF38393 HCl

[Synonym ]:
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1)
2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol hydrochloride
1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride (1:1)
1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-,hydrochloride
SKF 38393 (hydrochloride)

Biological Activity

[Description]:

SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.IC50 value: 110 nM [1]Target: D1 agonistin vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2]

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222.

[2]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-1070.

[3]. Chocyk A, et al. Dopamine D1-like receptors agonist SKF 38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus--impact of acute and chronic cocaine. J Physiol Pharmacol. 2008 Sep;59(3):425-440.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈ClNO₂

[ Molecular Weight ]:
291.773

[ Exact Mass ]:
291.102600

[ PSA ]:
52.49000

[ LogP ]:
3.50620

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

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