62717-42-4

62717-42-4 structure

Name: SKF38393 HCl
Chemical Name: 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride
CAS Number: 62717-42-4
Molecular Formula: C₁₆H₁₈ClNO₂
Molecular Weight: 291.773
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2017-02-06 08:59:51
Modify Date: 2024-01-03 10:32:42
SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.IC50 value: 110 nM [1]Target: D1 agonistin vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2]

Name	5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride
Synonyms	1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1) 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol hydrochloride 1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride (1:1) 1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-,hydrochloride SKF 38393 (hydrochloride)

Description	SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.IC50 value: 110 nM [1]Target: D1 agonistin vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. [2]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-1070. [3]. Chocyk A, et al. Dopamine D1-like receptors agonist SKF 38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus--impact of acute and chronic cocaine. J Physiol Pharmacol. 2008 Sep;59(3):425-440.

Molecular Formula	C₁₆H₁₈ClNO₂
Molecular Weight	291.773
Exact Mass	291.102600
PSA	52.49000
LogP	3.50620
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	22-26-36
RIDADR	NONH for all modes of transport

62717-42-4	2711717-77-8
1700663-41-7	1301757-19-6
707-75-5	183322-45-4
60719-82-6	860169-57-9
2022-29-9	66532-86-3