memantine hydrochloride

Names

[ Name ]:
memantine hydrochloride

[Synonym ]:
1,3-Dimethyl-5-aminoadamantane hydrochloride
Axura
3,5-Dimethyl-1-adamantanamine Hydrochloride
3,5-Dimethyladamantan-1-amine hydrochloride (1:1)
MFCD00214336
3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid
Ebixza
1-Amino-3,5-dimethyladamantane Hydrochloride
Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1)
3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride
Memantine Hydrochloride
3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate
Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride
Ebixia
SUN Y7017
3,5-Dimethyl-1-adamantanamine hydrochloride (1:1)
EINECS 255-219-6
tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride
3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1)
MemantineHCl
3,5-Dimethyladamantan-1-amine hydrochloride
Memantine HCL
Akatinol
Menantine Hydrochloride
Memantine (hydrochloride)

Biological Activity

[Description]:

Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[References]

[1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34.

[2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36.

[3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
239.8ºC at 760 mmHg

[ Melting Point ]:
292 °C

[ Molecular Formula ]:
C₁₂H₂₂ClN

[ Molecular Weight ]:
215.763

[ Flash Point ]:
92.3ºC

[ Exact Mass ]:
215.144073

[ PSA ]:
26.02000

[ LogP ]:
4.19640

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Related Compounds

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