DNQX

Names

[ Name ]:
DNQX

[Synonym ]:
6,7-Dinitro-1,4-dihydro-2,3-quinoxalinedione
6,7-dinitroquinoxaline-2,3-diol
2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-
MFCD00069257
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione
DNQX

Biological Activity

[Description]:

DNQX is a AMPA receptor antagonists.target: AMPA receptorIn vitro: DNQX, added 2 h after cell plating, induces a dose-dependent neurotoxicity.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Cancer

[References]

[1]. Watkins JC et al. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol Sci. 1990 Jan;11(1):25-33.

[2]. Honoré T et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988 Aug 5;241(4866):701-3.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
670.7ºC at 760 mmHg

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₈H₄N₄O₆

[ Molecular Weight ]:
252.141

[ Flash Point ]:
359.4ºC

[ Exact Mass ]:
252.013077

[ PSA ]:
157.36000

[ LogP ]:
1.13

[ Vapour Pressure ]:
1.33E-18mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
Desiccate at RT

[ Stability ]:
Store in freezer at -20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.

Acta Physiol. (Oxf.) 214 , 261-74, (2015)

The primary aim of this study was to identify the effects of hyperammonaemia on functional expression of Cav1.2 L-type Ca(2+) channels in astroglia.Primary cultures of mouse astrocytes were used to st...

Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.

J. Neurosci. 34(21) , 7137-47, (2014)

GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various netwo...

Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.

J. Neurosci. 35(14) , 5664-79, (2015)

The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2...

Related Compounds

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