<Suppliers Price>

Naspm

Names

[ CAS No. ]:
122306-11-0

[ Name ]:
Naspm

[Synonym ]:
1-naphthylacetylspermine
NASPM trihydrochloride
Naspm

Biological Activity

[Description]:

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease

[In Vitro]

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

[References]

[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.


[Related Small Molecules]

(+)-MK 801 Maleate | CNQX | N-Methyl-D-aspartic acid | ifenprodil tartrate | D-AP5(mM/ml) | DNQX | Ro 25-6981 maleate | Flupirtine maleate | Mibampator | CX546 | Talampanel | Centrophenoxine hydrochloride | Naspm (trihydrochloride) | 24-Hydroxycholesterol

Chemical & Physical Properties

[ Density]:
1.062g/cm3

[ Boiling Point ]:
608.9ºC at 760mmHg

[ Molecular Formula ]:
C22H34N4O

[ Molecular Weight ]:
370.53

[ Flash Point ]:
322.1ºC

[ PSA ]:
79.18000

[ LogP ]:
4.83560

[ Vapour Pressure ]:
9.01E-15mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
2-8℃

Safety Information

[ Safety Phrases ]:
S22

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.