<Suppliers Price>

DNQX disodium salt

Names

[ CAS No. ]:
1312992-24-7

[ Name ]:
DNQX disodium salt

[Synonym ]:
2,3-Quinoxalinedione, 1,4-dihydro-6,7-dinitro-, sodium salt (1:2)
Disodium 6,7-dinitro-2,3-quinoxalinediolate
Disodium 6,7-dinitroquinoxaline-2,3-diolate

Biological Activity

[Description]:

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

Non-NMDA Receptor[1]


[In Vitro]

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].

[In Vivo]

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].

[References]

[1]. Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241(4866):701-703.

[2]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103(4):1728-1734.

[3]. Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687(1-2):114-124.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H2N4Na2O6

[ Molecular Weight ]:
296.104

[ Exact Mass ]:
295.976959

Related Compounds