ifenprodil tartrate

Names

[ Name ]:
ifenprodil tartrate

[Synonym ]:
Ifenprodil Tartrate
Ifenprodil (+)-tartrate salt
Ifenprodil (tartrate)

Biological Activity

[Description]:

Ifenprodil tartrate is a novel N-methyl-D-aspartate (NMDA) receptor antagonist that selectively inhibits receptors containing the NR2B subunit.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[References]

[1]. Gotti B, et al. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. J Pharmacol Exp Ther. 1988 Dec;247(3):1211-21.

[2]. Reynolds IJ, et al. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol Pharmacol. 1989 Nov;36(5):758-65.

[3]. Schoemaker H, et al. Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex. Eur J Pharmacol. 1990 Feb 6;176(2):249-50.

[4]. Shalaby IA, et al. Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J Pharmacol Exp Ther. 1992 Feb;260(2):925-32.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
493.5ºC at 760mmHg

[ Melting Point ]:
178-180ºC

[ Molecular Formula ]:
C₂₁H₂₇NO_2.1/₂C₄H₆O₆

[ Molecular Weight ]:
400.49

[ Flash Point ]:
248.7ºC

[ PSA ]:
158.76000

[ LogP ]:
1.58410

[ Vapour Pressure ]:
0mmHg at 25°C

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
22-26-36-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.

J. Neurosci. 33(38) , 15259-71, (2013)

Panic attacks are a hallmark in panic disorder (PAND). During the panic attack, a strong association with the surrounding context is established suggesting that the hippocampus may be critically invol...

Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.

J. Neurosci. 33(3) , 1109-15, (2013)

Signaling at NMDA receptors (NMDARs) is known to be important for memory reconsolidation, but while most studies show that NMDAR antagonists prevent memory restabilization and produce amnesia, others ...

Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.

Pain 153 , 1022-1029, (2012)

N-Methyl-d-aspartate (NMDA) receptors are thought to play an important role in the processes of central sensitization and pathogenesis of neuropathic pain, particularly after spinal cord injury (SCI)....