memantine hydrochloride

Modify Date: 2024-01-02 10:10:33

memantine hydrochloride structure	Common Name	memantine hydrochloride
	CAS Number	41100-52-1	Molecular Weight	215.763
	Density	N/A	Boiling Point	239.8ºC at 760 mmHg
	Molecular Formula	C₁₂H₂₂ClN	Melting Point	292 °C
	MSDS	USA	Flash Point	92.3ºC

Use of memantine hydrochloride

Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].

Name	memantine hydrochloride
Synonym	More Synonyms

Description	Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
References	[1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34. [2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36. [3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

References

[1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34.

[2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36.

[3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.

Boiling Point	239.8ºC at 760 mmHg
Melting Point	292 °C
Molecular Formula	C₁₂H₂₂ClN
Molecular Weight	215.763
Flash Point	92.3ºC
Exact Mass	215.144073
PSA	26.02000
LogP	4.19640
Storage condition	-20°C Freezer

memantine hydrochloride MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2921300090

Precursor 10
CAS#:19982-07-1 1-Acetamido-3,5... CAS#:351329-88-9 1-Formylamino-3... CAS#:19982-08-2 memantine CAS#:707-36-8 1-Chloro-3,5-di...
CAS#:947238-46-2 2-chloro-N-(3,5... CAS#:1058345-42-8 2,2,2-trichloro... CAS#:702-79-4 1,3-Dimethylada... CAS#:75-05-8 Acetonitrile
CAS#:707-37-9 1-hydroxy-3,5-d... CAS#:941-37-7 1-Bromo-3,5-dim...
DownStream 1
CAS#:19982-08-2 memantine

HS Code	2921300090
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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1,3-Dimethyl-5-aminoadamantane hydrochloride

Axura

3,5-Dimethyl-1-adamantanamine Hydrochloride

3,5-Dimethyladamantan-1-amine hydrochloride (1:1)

MFCD00214336

3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid

Ebixza

1-Amino-3,5-dimethyladamantane Hydrochloride

Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1)

3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride

Memantine Hydrochloride

3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate

Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride

Ebixia

SUN Y7017

3,5-Dimethyl-1-adamantanamine hydrochloride (1:1)

EINECS 255-219-6

tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride

3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1)

MemantineHCl

3,5-Dimethyladamantan-1-amine hydrochloride

Memantine HCL

Akatinol

Menantine Hydrochloride

Memantine (hydrochloride)

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China
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DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Memantine hydrochloride
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Memantine HCl;Memantine Hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Memantine HCl
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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memantine hydrochloride

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