2-Hydroxy-2-methylbutyric acid

Names

[ Name ]:
2-Hydroxy-2-methylbutyric acid

[Synonym ]:
2-hydroxy-2-methyl-butyric acid
2-Hydroxy-2-methyl-n-butyric acid
2-Hydroxy-2-methylbutyric acid
EINECS 223-120-7
2-Hydroxy-2-methylbutanoic acid
Butanoic acid, 2-hydroxy-2-methyl-
2-hydroxy-2-methyl-butanoic acid
MFCD00004476

Biological Activity

[Description]:

2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Dekant W, et al. Biotransformation of MTBE, ETBE, and TAME after inhalation or ingestion in rats and humans. Res Rep Health Eff Inst. 2001 May;(102):29-71; discussion 95-109.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
237.6±13.0 °C at 760 mmHg

[ Melting Point ]:
73-75 °C(lit.)

[ Molecular Formula ]:
C₅H₁₀O₃

[ Molecular Weight ]:
118.131

[ Flash Point ]:
111.8±16.3 °C

[ Exact Mass ]:
118.062996

[ PSA ]:
57.53000

[ LogP ]:
0.18

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.460

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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