Tiglic acid
Names
[ CAS No. ]:
80-59-1
[ Name ]:
Tiglic acid
[Synonym ]:
(2E)-2-Methyl-2-butenoic acid
2-Butenoic acid, 2-methyl-, (2E)-
FEMA 3599
2,3-Dimethylacrylic acid
EINECS 201-295-0
(2E)-2-Methylbut-2-enoic acid
Cevadic acid
Tiglic acid
E-Tiglic acid
MFCD00066864
Tiglate
(E)-2-methyl-2-butenoic acid
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
198.5±0.0 °C at 760 mmHg
[ Melting Point ]:
61-64 °C(lit.)
[ Molecular Formula ]:
C5H8O2
[ Molecular Weight ]:
100.116
[ Flash Point ]:
95.9±9.6 °C
[ Exact Mass ]:
100.052429
[ PSA ]:
37.30000
[ LogP ]:
1.35
[ Vapour Pressure ]:
0.2±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.451
[ Storage condition ]:
Refrigerator (+4°C)
[ Water Solubility ]:
SOLUBLE IN HOT WATER
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GQ5430000
- CHEMICAL NAME :
- Crotonic acid, 2-methyl-, (E)-
- CAS REGISTRY NUMBER :
- 80-59-1
- BEILSTEIN REFERENCE NO. :
- 1236500
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C5-H8-O2
- MOLECULAR WEIGHT :
- 100.13
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,837,1982 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,837,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,837,1982
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25
[ RIDADR ]:
UN 3261 8/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
GQ5430000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29161980
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29161980
Articles
Planta Med. 75 , 528-33, (2009)
Three unusual tiglic acid-containing cyclodepsipeptides, possessing the revised regioisomeric structures for largamides A-C (1-3), have been isolated from the marine cyanobacterium Lyngbya confervoide...
Pathway of formation of branched-chain volatile fatty acids in Ascaris mitochondria.J. Parasitol. 67(6) , 841-6, (1981)
Disrupted Ascaris mitochondria formed 2-methylbutyrate (2-MB) and 2-methylvalerate (2-MV) when incubated anaerobically with acetyl CoA, propionyl CoA and NADH. However, when mitochondrial membranes we...
Biosynthesis of tiglic, ethacrylic, and 2-methylbutyric acids in a carabid beetle, Pterostichus (Hypherpes) californicus.J. Chem. Ecol. 33(5) , 963-70, (2007)
Tiglic, 2-methylbutyric, and ethacrylic acids are found in the pygidial gland defensive fluid of many carabid beetles. By injecting a deuterium-labeled precursor into the carabid beetle Pterostichus (...