Tigloidin

Names

[ CAS No. ]:
495-83-0

[ Name ]:
Tigloidin

[Synonym ]:
(E)-2-methylbut-2-enoic acid methyl ester
Methyl-2-methylcrotonat
methyl 2-methylcrotonate
2-Carbomethoxy-2-bute
methylalpha-methylcrotonate
tiglic acid methyl ester
(E)-methyl 2-methylbut-2-enoate
dimethylacrylic acid methyl ester
Tiglinsaeure-tropan-3exo-ylester
methyl (E)-2,3-dimethylpropenolate
Tiglic acid methyl
Methyltiglate
tiglic acid tropane-3exo-yl ester
2-methyl-but-2-enoic acid methyl ester
methyl(e)-2-methylcrotonate
Tigloidin

Biological Activity

[Description]:

Tigloidin is an analogue of atropine, with anticholinergic activity.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vivo]

Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats[1].

[References]

[1]. Sanghvi I, et al. Pharmacology of a potential anti-Parkinson agent: tigloidine. Eur J Pharmacol. 1968 Oct;4(3):246-53.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
290.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₁NO₂

[ Molecular Weight ]:
223.31100

[ Flash Point ]:
99.9ºC

[ Exact Mass ]:
223.15700

[ PSA ]:
29.54000

[ LogP ]:
2.05890

[ Vapour Pressure ]:
0.0021mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
2-8℃

Tigloidin

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds