5,7-Dihydroxychromone

Names

[ Name ]:
5,7-Dihydroxychromone

[Synonym ]:
4H-1-Benzopyran-4-one, 5,7-dihydroxy-
5,7-dihydroxy-4H-1-benzopyran-4-one
5,7-Dihydroxychromone
2H-1-Benzopyran-2-one, 5,7-dihydroxy-
5,7-Dihydroxy-4H-chromen-4-one
5,7-Dihydroxy-2H-chromen-2-one
5,7-dihydroxy-chromen-4-one
5,7-Dihydroxy-chromen-4-on
5,7-DIHYDROXYCOUMARIN

Biological Activity

[Description]:

5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Arenavirus

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Neurological Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

Nrf2

Caspase-3

Caspase-9

PARP

[References]

[1]. Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
399.4±42.0 °C at 760 mmHg

[ Melting Point ]:
232-273℃

[ Molecular Formula ]:
C₉H₆O₄

[ Molecular Weight ]:
178.141

[ Flash Point ]:
170.8±21.4 °C

[ Exact Mass ]:
178.026611

[ PSA ]:
70.67000

[ LogP ]:
0.54

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.689

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

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