Homovanillic acid

Names

[ CAS No. ]:
306-08-1

[ Name ]:
Homovanillic acid

[Synonym ]:
Homovanillinic acid
2-(4-Hydroxy-3-methoxyphenyl)acetic acid
HOMORANILLIC ACID
EINECS 206-176-7
4-Hydroxy-3-methoxy-a-toluic Acid
2-(4-hydroxy-3-methoxyphenyl)ethanoic acid
RARECHEM AL BO 0135
Vanillacetic Acid
Vanilacetic acid
Benzeneacetic acid, 4-hydroxy-3-methoxy-
(4-Hydroxy-3-methoxyphenyl)acetic acid
3-methoxy-4-hydroxyphenylacetic acid
HVA
MFCD00004350
4-Hydroxy-3-methoxyphenylacetic Acid
Homovanillic acid
Homovanillate
Homovaniuic acid
HomovanillicAcid
Methoxy-4-Hydroxyphenylacetate
3-methoxy-4-hydroxy-phenylacetic acid
Homovanilic acid
4-Hydroxy-3-methoxyphenylacetic acid HVA

Biological Activity

[Description]:

Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
368.7±27.0 °C at 760 mmHg

[ Melting Point ]:
142-145 °C(lit.)

[ Molecular Formula ]:
C₉H₁₀O₄

[ Molecular Weight ]:
182.173

[ Flash Point ]:
151.9±17.2 °C

[ Exact Mass ]:
182.057907

[ PSA ]:
66.76000

[ LogP ]:
0.47

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Permeation of Dopamine Sulfate through the Blood-Brain Barrier.

PLoS ONE 10 , e0133904, (2015)

Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from per...

Toxicity of copper on isolated liver mitochondria: impairment at complexes I, II, and IV leads to increased ROS production.

Cell Biochem. Biophys. 70(1) , 367-81, (2014)

Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+),...

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.

J. Pharmacol. Exp. Ther. 350(3) , 589-604, (2014)

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for ser...