3'-Methoxydaidzein

Names

[ CAS No. ]:
21913-98-4

[ Name ]:
3'-Methoxydaidzein

[Synonym ]:
Isoflavone,4',7-dihydroxy-3'-methoxy
3'-Methoxydaidzein
7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-
4',7-dihydroxy-3'-methoxyisoflavone
7,4'-dihydroxy-3'-methoxy-isoflavone
7-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one

Biological Activity

[Description]:

3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

Nav1.3:505 nM (IC50)

Nav1.7:181 nM (IC50)

Nav1.8:397 nM (IC50)

[References]

[1]. Xu RJ, et al. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. Chin J Nat Med. 2019 Jun;17(6):413-423.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
534.5±50.0 °C at 760 mmHg

[ Melting Point ]:
258-260℃

[ Molecular Formula ]:
C₁₆H₁₂O₅

[ Molecular Weight ]:
284.26

[ Flash Point ]:
204.8±23.6 °C

[ Exact Mass ]:
284.068481

[ PSA ]:
79.90000

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.669

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%