CP-409092

Names

[ CAS No. ]:
194098-25-4

[ Name ]:
CP-409092

[Synonym ]:
420WLS764W
CP-409092
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N-[4-[(methylamino)methyl]phenyl]-4-oxo-
N-{4-[(Methylamino)methyl]phenyl}-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide

Biological Activity

[Description]:

CP-409092 is a GABA(A) partial agonist, used for the treatment of anxiety.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Research Areas >> Neurological Disease

[In Vivo]

The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [14C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats[1].

[References]

[1]. Kamel A, et al. Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats. Xenobiotica. 2010 Jun;40(6):400-14.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
475.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₉N₃O₂

[ Molecular Weight ]:
297.352

[ Flash Point ]:
241.1±28.7 °C

[ Exact Mass ]:
297.147736

[ LogP ]:
0.85

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds

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