GNE 0723

Names

[ CAS No. ]:
1883518-31-7

[ Name ]:
GNE 0723

[Synonym ]:
Cyclopropanecarbonitrile, 2-[7-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-5-oxo-2-(trifluoromethyl)-5H-thiazolo[3,2-a]pyrimidin-3-yl]-, (1R,2R)-
(1R,2R)-2-[7-{[5-Chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-5-oxo-2-(trifluoromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropanecarbonitrile
MFCD30829912

Biological Activity

[Description]:

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease

[Target]

EC50: 21 nM (GluN2A), 7.4 μM (GluN2C), 6.2 μM (GluN2D)[1]


[In Vitro]

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].

[References]

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.


[Related Small Molecules]

(+)-MK 801 Maleate | CNQX | N-Methyl-D-aspartic acid | ifenprodil tartrate | D-AP5(mM/ml) | DNQX | Ro 25-6981 maleate | Flupirtine maleate | Mibampator | CX546 | Naspm | Talampanel | Centrophenoxine hydrochloride | 24-Hydroxycholesterol

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
505.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H8ClF6N5OS

[ Molecular Weight ]:
467.776

[ Flash Point ]:
259.4±32.9 °C

[ Exact Mass ]:
467.004242

[ LogP ]:
2.89

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.680

Related Compounds