GNE-0439

Names

[ CAS No. ]:
1241902-40-8

[ Name ]:
GNE-0439

Biological Activity

[Description]:

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.34 uM (Nav1.7)[1]

[References]

[1]. Chernov-Rogan T, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₁NO₃

[ Molecular Weight ]:
345.48

Safety Information

[ Hazard Codes ]:
Xi

GNE-0439

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds