7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Names

[ Name ]:
7-Chloro-4-hydroxyquinoline-2-carboxylic acid

[Synonym ]:
7-chloro-4-hydroxyquinoline-2-carboxylic acid
7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
7-Chlorokynurenic acid
MFCD00674924
EINECS 241-913-6
7-chloro-4-hydroxy-2-carboxyquinoline
7-Cl-KYNA

Biological Activity

[Description]:

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[Target]

N-methyl-D-aspartate receptor[1] Ki: 0.59 μM (reuptake of glutamate)[1]

[References]

[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.

[2]. Bartlett RD, et al. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology. 1998 Jul;37(7):839-46.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.549 g/cm3

[ Boiling Point ]:
395ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₆ClNO₃

[ Molecular Weight ]:
223.61300

[ Flash Point ]:
192.7ºC

[ Exact Mass ]:
223.00400

[ PSA ]:
70.42000

[ LogP ]:
2.29200

[ Vapour Pressure ]:
6E-07mmHg at 25°C

[ Index of Refraction ]:
1.648

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
0.1 M NaOH: 13.7 mg/mL

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%