18000-24-3

18000-24-3 structure

Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Chemical Name: 7-chlorokynurenic acid
CAS Number: 18000-24-3
Molecular Formula: C₁₀H₆ClNO₃
Molecular Weight: 223.61300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-07-13 15:32:13
Modify Date: 2024-01-10 19:23:35
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.

Name	7-chlorokynurenic acid
Synonyms	7-chloro-4-hydroxyquinoline-2-carboxylic acid 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid 7-Chlorokynurenic acid MFCD00674924 EINECS 241-913-6 7-chloro-4-hydroxy-2-carboxyquinoline 7-Cl-KYNA

Description	7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	N-methyl-D-aspartate receptor[1] Ki: 0.59 μM (reuptake of glutamate)[1]
References	[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. [2]. Bartlett RD, et al. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology. 1998 Jul;37(7):839-46.

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
WGK Germany	3
HS Code	2933499090

108-42-9

18000-24-3

Literature: Journal of the American Chemical Society, , vol. 68, p. 113,115

21640-97-1

18000-24-3

Literature: Chemische Berichte, , vol. 81, p. 499,505 Journal of the American Chemical Society, , vol. 68, p. 113,115

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%