3-Hydroxymandelic Acid

Names

[ Name ]:
3-Hydroxymandelic Acid

[Synonym ]:
3-Hydroxy-mandelsaeure
3-Hydroxymandelic Acid
EINECS 241-182-3
M-hydroxymandelate
MFCD00042723
m-Hydroxymandelic acid
MHMA
3-Hydroxyphenylglycolic acid
2-hydroxy-2-(3-hydroxyphenyl)acetic acid

Biological Activity

[Description]:

3-Hydroxymandelic Acid, a metabolite of Phenylephrine, Phenylephrine is a α-receptor agonist.

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

Phenylephrine, an alpha-receptor agonist is metabolized to m-hydroxyphenylglycol (MHPG) and m-hydroxymandelic acid (MHMA) in the human body[1]. It is probable that urinary MHMA originates from m-octopamine or m-synephrine (Phenylephrine) or both[1].

[References]

[1]. Gumbhir K, et al. Determination of m-hydroxymandelic acid, m-hydroxyphenylglycol and their conjugates in human plasma using liquid chromatography with electrochemical detection. J Pharm Biomed Anal. 1994 Jul;12(7):943-9.

[2]. Crowley JR, et al. Normal excretion of m-hydroxymandelic acid in hypertensive patients. Clin Chim Acta. 1981 Jan 22;109(2):125-31.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
424.3ºC at 760mmHg

[ Melting Point ]:
128-132ºC

[ Molecular Formula ]:
C₈H₈O₄

[ Molecular Weight ]:
168.14700

[ Flash Point ]:
224.5ºC

[ Exact Mass ]:
168.04200

[ PSA ]:
77.76000

[ LogP ]:
0.51020

[ Vapour Pressure ]:
5.91E-08mmHg at 25°C

[ Index of Refraction ]:
1.637

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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J. Clin. Gastroenterol. 33(1) , 36-40, (2001)

D-Xylose absorption testing is a simple, low-cost method of screening for small intestinal malabsorption. The optimum method to measure D-xylose absorption (serum vs. urine testing) is uncertain.We pr...

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