Tyrphostin AG 1112

Names

[ Name ]:
Tyrphostin AG 1112

Biological Activity

[Description]:

Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase

Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase

[In Vitro]

Tyrphostin AG1112 (0-100 μM) dose-dependently induces differentiation also induce specific growth arrest[1].

[References]

[1]. T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8.

[2]. M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₀N₆

[ Molecular Weight ]:
274.28

[ Appearance of Characters ]:
solid

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38-40

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Protein kinase inhibitors as a therapeutic modality.

Acc. Chem. Res. 36(6) , 462-9, (2003)

Most of the signal transduction pathways are mediated by protein kinases regulating every aspect of cell function. Mutations which deregulate their expression or their function or both result in cance...

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.

Blood 82(12) , 3524-9, (1993)

We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid diff...