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Tyrphostin AG 528

Names

[ CAS No. ]:
133550-49-9

[ Name ]:
Tyrphostin AG 528

[Synonym ]:
N-(3',4'-dihydroxybenzylidenecyanoacetyl)indoline
(E)-2-(2,3-Dihydro-indole-1-carbonyl)-3-(3,4-dihydroxy-phenyl)-acrylonitrile

Biological Activity

[Description]:

Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.

[Related Catalog]:

Research Areas >> Cancer

[Target]

EGFR:4.9 μM (IC50)

ErbB2:2.1 μM (IC50)


[References]

[1]. Naijue Zhu, et al. Tyrphostin Tumor Growth Inhibitors of EGFR and ErbB2 Tyrosine Kinase. J Chem Crystallogr. 2007, 37, 679–683.


[Related Small Molecules]

Osimertinib (AZD9291) | Tyrphostin B42 (AG-490) | Neratinib (HKI-272) | Genistein | (-)-Epigallocatechin gallate | AG-1478 | Dacomitinib (PF-00299804) | Irbinitinib | Poziotinib | Olmutinib | Sapitinib | AZD-3759 | Pyrotinib | Canertinib dihydrochloride | BMS-690514

Chemical & Physical Properties

[ Melting Point ]:
215 °C

[ Molecular Formula ]:
C18H14N2O3

[ Molecular Weight ]:
306.31500

[ Exact Mass ]:
306.10000

[ PSA ]:
84.56000

[ LogP ]:
2.65908

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Related Compounds