TYRPHOSTIN AG 1290

Names

[ Name ]:
TYRPHOSTIN AG 1290

[Synonym ]:
unii-3u917c92qr
(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylic acid
ss-3041
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-, (2E)-

Biological Activity

[Description]:

Entacapone acid (Tyrphostin AG1290) is a tyrosine kinase inhibitor. Entacapone acid reduces hepatic protein synthesis rate (HPS) in vivo[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

Tyrosine kinase[1]

[References]

[1]. Nakagohri T, et al. The effects of prostaglandin E1 and tyrosine kinase inhibitors on energy status and protein synthetic ability in hepatic ischemia-reperfusion injury. Surg Today. 1998;28(5):517-21.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
478.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₆N₂O₆

[ Molecular Weight ]:
250.164

[ Flash Point ]:
243.4±28.7 °C

[ Exact Mass ]:
250.022583

[ PSA ]:
147.37000

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.750

Precursor & DownStream

Precursor

DownStream

Related Compounds

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