Tyrphostin AG 1478
Names
[ CAS No. ]:
175178-82-2
[ Name ]:
Tyrphostin AG 1478
[Synonym ]:
n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin
4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-
Tyrphostin AG 1478
4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline
MFCD00270914
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
458.5±45.0 °C at 760 mmHg
[ Molecular Formula ]:
C16H14ClN3O2
[ Molecular Weight ]:
315.754
[ Flash Point ]:
231.1±28.7 °C
[ Exact Mass ]:
315.077454
[ PSA ]:
56.27000
[ LogP ]:
3.77
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.668
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
0.1 M HCl: soluble <0.4 mg/mL
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Br. J. Pharmacol. 172 , 3028-42, (2015)
Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved ...
Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis.J. Neurosci. Res. 93(1) , 130-9, (2014)
The cotransporter of Na(+) , K(+) , 2Cl(-) , and water, NKKC1, is activated under two conditions in the brain, exposure to highly elevated extracellular K(+) concentrations, causing astrocytic swellin...
Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.BMC Cancer 11 , 421, (2011)
Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear. We have examined signalli...