(S)-MCPG

Names

[ Name ]:
(S)-MCPG

[Synonym ]:
(+)-MCPG
(S)-alpha-Methyl-4-carboxyphenylglycine
4-[(1S)-1-amino-1-carboxyethyl]benzoic acid
(S)-MCPG

Biological Activity

[Description]:

(S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Bordi F et al. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology. 1996;35(11):1557-65.

[2]. Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol. 1996 Apr;117(7):1493-503.

[3]. Jane DE et al. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 1993 Jul;32(7):725-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
425.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₁NO₄

[ Molecular Weight ]:
209.19900

[ Flash Point ]:
211ºC

[ Exact Mass ]:
209.06900

[ PSA ]:
100.62000

[ LogP ]:
1.34360

[ Vapour Pressure ]:
5.44E-08mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.

Neuropharmacology 32 , 725, (1993)

The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the ...

Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG.

J. Neurosci. 15 , 87-98, (1995)

Metabotropic glutamate receptors (mGluRs) are critically involved in the maintenance of long-term potentiation (LTP) (Reymann and Matthies, 1989; Behnisch et al., 1991; Izumi et al., 1991; Bashir et a...