JNJ-40411813
Names
[ CAS No. ]:
1127498-03-6
[ Name ]:
JNJ-40411813
[Synonym ]:
1'-butyl-3'-chloro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-one
JNJ-40411813
Biological Activity
[Description]:
JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H25ClN2O
[ Molecular Weight ]:
344.87800
[ Exact Mass ]:
344.16600
[ PSA ]:
25.24000
[ LogP ]:
4.75080
[ Storage condition ]:
2-8℃