Dipraglurant

Names

[ Name ]:
Dipraglurant

[Synonym ]:
Dipraglurant
CS-0690
Dipraglurant [INN]
UNII-CV8JZR21A1

Biological Activity

[Description]:

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

[Related Small Molecules]

mavoglurant | L-Glutamine | CTEP (RO4956371) | LY 354740 | L-(+)Sodium glutamate | ADX-88178 | MPEP (Hydrochloride) | FITM | (S)-MCPG | Basimglurant | LY341495 | JNJ-40411813 | LY404039 | JNJ 16259685 | ADX-47273

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂FN₃

[ Molecular Weight ]:
265.28500

[ Exact Mass ]:
265.10200

[ PSA ]:
30.19000

[ LogP ]:
2.85270