(S)-MCPG
Modify Date: 2025-08-27 17:53:35
(S)-MCPG structure
|
Common Name | (S)-MCPG | ||
|---|---|---|---|---|
| CAS Number | 150145-89-4 | Molecular Weight | 209.19900 | |
| Density | N/A | Boiling Point | 425.3ºC at 760mmHg | |
| Molecular Formula | C10H11NO4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 211ºC | |
Use of (S)-MCPG(S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG. |
| Name | (s)-alpha-methyl-4-carboxyphenylglycine |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist. In vivo: (S)-MCPG (20.8 μg) injected intraventricularly (i.c.v.) before testing impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. Memory retention, evaluated 24 hr post-training, is also affected by the high dose of MCPG. |
|---|---|
| Related Catalog | |
| References |
| Boiling Point | 425.3ºC at 760mmHg |
|---|---|
| Molecular Formula | C10H11NO4 |
| Molecular Weight | 209.19900 |
| Flash Point | 211ºC |
| Exact Mass | 209.06900 |
| PSA | 100.62000 |
| LogP | 1.34360 |
| Vapour Pressure | 5.44E-08mmHg at 25°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2922499990 |
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
|
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
Neuropharmacology 32 , 725, (1993) The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the ... |
|
|
Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG.
J. Neurosci. 15 , 87-98, (1995) Metabotropic glutamate receptors (mGluRs) are critically involved in the maintenance of long-term potentiation (LTP) (Reymann and Matthies, 1989; Behnisch et al., 1991; Izumi et al., 1991; Bashir et a... |
| (+)-MCPG |
| (S)-alpha-Methyl-4-carboxyphenylglycine |
| 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid |
| (S)-MCPG |