Naltrindole hydrochloride
Names
[ CAS No. ]:
111469-81-9
[ Name ]:
Naltrindole hydrochloride
[Synonym ]:
MFCD00069313
NTI
NTI hydrochloride
Naltrindole (hydrochloride)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Ki: 0.02 nM (δ opioid), 64 nM (μ opioid), 66 nM (κ opioid)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
664.2ºC at 760mmHg
[ Molecular Formula ]:
C26H27ClN2O3
[ Molecular Weight ]:
450.95700
[ Flash Point ]:
355.5ºC
[ Exact Mass ]:
450.17100
[ PSA ]:
68.72000
[ LogP ]:
4.31250
[ Vapour Pressure ]:
1.51E-18mmHg at 25°C
[ Storage condition ]:
2-8℃
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Eur. J. Pharmacol. 146 , 185, (1988)
Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.
Eur. J. Pharmacol. 390 , 1-6, (2000)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of ...
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.Pflugers Arch. 439 , 547-554, (2000)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, ...