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Met-Enkephalin acetate salt

Names

[ CAS No. ]:
58569-55-4

[ Name ]:
Met-Enkephalin acetate salt

[Synonym ]:
MET-enkephalin
ENKEPHALIN,METHIONINE
1-5-Adrenorphin (human)
H-Tyr(1)-Gly(2)-Gly(3)-Phe(4)-Met(5)-OH
Methionine enkephalin
[Met5]-enkephalin
TYR-GLY-GLY-PHE-MET
Opioid growth factor
H-Tyr-Gly-Gly-Phe-Met-OH
EINECS 261-335-8
Tyr-Gly-Gly-Phe-Met-OH
Lupex

Biological Activity

[Description]:

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease
Peptides

[Target]

Opioid Receptor[1].


[In Vitro]

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1].

[References]

[1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.


[Related Small Molecules]

PZM-21 | Loperamide hydrochloride | Oliceridine hydrochloride | ADL5859 HCl | JDTic (dihydrochloride) | Naltrindole hydrochloride | LY-2456302 | JTC-801 | Matrine | Cebranopadol | Leu-Enkephalin | DAMGO | Sinomenine HCl | SR17018 | Endomorphin 1

Chemical & Physical Properties

[ Density]:
1.324 g/cm3

[ Boiling Point ]:
1052.9ºC at 760 mmHg

[ Molecular Formula ]:
C27H35N5O7S

[ Molecular Weight ]:
573.66100

[ Flash Point ]:
590.6ºC

[ Exact Mass ]:
573.22600

[ PSA ]:
225.25000

[ LogP ]:
1.80830

[ Index of Refraction ]:
1.608

[ Storage condition ]:
−20°C

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds