Leu-Enkephalin

Names

[ Name ]:
Leu-Enkephalin

[Synonym ]:
LEU-ENKEPHALIN
H-TyrGlyGlyPheLeu-OH
EINECS 261-457-1
L-TYR-GLY-GLY-PHE-LEU
SGS 518 oxalate
LEUCINE-ENKEPHALIN
Leu-Enkelphalin
L-leucine enkephalin
enkephalin,leucine
MFCD00076406
ENKEPHALIN L
TYR-GLY-GLY-PHE-LEU
YGGFL
H2N-Tyr-Gly-Gly-Phe-Leu-COOH

Biological Activity

[Description]:

[Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Peptides

Research Areas >> Neurological Disease

[Target]

Opioid receptors[1]

[In Vitro]

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].

[References]

[1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

[2]. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May 15;77(2):209-13.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.274 g/cm3

[ Boiling Point ]:
998.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₇N₅O₇

[ Molecular Weight ]:
555.62300

[ Flash Point ]:
557.8ºC

[ Exact Mass ]:
555.26900

[ PSA ]:
199.95000

[ LogP ]:
2.10130

[ Index of Refraction ]:
1.586

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in water (1 mg/ml ).

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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