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Remimazolam benzenesulfonate

Names

[ CAS No. ]:
1001415-66-2

[ Name ]:
Remimazolam benzenesulfonate

[Synonym ]:
CN-7056 benzenesulfonate
methyl (S)-3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate benzenesulfonate
Remimazolam (benzenesulfonate)

Biological Activity

[Description]:

Remimazolam benzenesulfonate is a GABA agonist。Target: GABA ReceptorRemimazolam acts on GABA receptor, specifically GABA-alpha. Remimazolam is a new drug innovation in anesthesia. Remimazolam combines the properties of two unique drugs already established in anesthesia - Midazolam and remifentanil. Remimazolam acts on GABA receptors like midazolam and has organ-independent metabolism like remifentanil. Remimazolam is likely to be the sedative of the future, as preliminary phase II trials have shown minimal residual effects on prolonged infusions. Remimazolam has potential to be used as a sedative in ICU and as a novel agent for procedural sedation.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Research Areas >> Neurological Disease

[References]

[1]. Goudra BG, et al. Remimazolam: The future of its sedative potential. Saudi J Anaesth. 2014 Jul;8(3):388-391.


[Related Small Molecules]

(+)-Bicuculline | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Riluzole | Baclofen | basmisanil | (R)-Baclofen | Etifoxine | Etomidate | Ginkgolide A | NS-11394 | 5alpha-Pregnan-3alpha-ol-20-one | CGP 52432 | L-655,708 | SAGE-217

Chemical & Physical Properties

[ Molecular Formula ]:
C27H25BrN4O5S

[ Molecular Weight ]:
597.48000

[ Exact Mass ]:
596.07300

[ PSA ]:
132.12000

[ LogP ]:
5.63320

[ Storage condition ]:
2-8℃

Related Compounds