HIF-1 inhibitor-4

Modify Date: 2024-04-05 18:15:55

Use of HIF-1 inhibitor-4

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].

Name	WAY-299838
Synonym	More Synonyms

Description	HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
In Vitro	HIF-1 inhibitor-4 (Compound 1) 抑制 HIF-1，IC50 为 560 nM (使用 U251 细胞进行定量，在 VEGF 启动子 (VEGF-PLAP) 的控制下表达 PLAP 报告基因)[1]。
References	[1]. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29.

Molecular Formula	C₁₈H₁₉IN₂O₂
Molecular Weight	422.26013

Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-