Pim-1 Inhibitor 2

Modify Date: 2024-01-03 15:06:10

Pim-1 Inhibitor 2 Structure
Pim-1 Inhibitor 2 structure
Common Name Pim-1 Inhibitor 2
CAS Number 477845-12-8 Molecular Weight 322.74800
Density N/A Boiling Point N/A
Molecular Formula C17H11ClN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pim-1 Inhibitor 2


PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

 Names

Name 4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine
Synonym More Synonyms

 Pim-1 Inhibitor 2 Biological Activity

Description PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].
Related Catalog
Target

PIM1:91 nM (Ki)

References

[1]. Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51(6):1972-5.

 Chemical & Physical Properties

Molecular Formula C17H11ClN4O
Molecular Weight 322.74800
Exact Mass 322.06200
PSA 77.83000
LogP 4.76860

 Synonyms

3bgp
PIM-1 INHIBITOR 2
benzisoxazole-pyrimidine,2