477845-12-8

477845-12-8 structure

Name: Pim-1 Inhibitor 2
Chemical Name: 4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine
CAS Number: 477845-12-8
Molecular Formula: C₁₇H₁₁ClN₄O
Molecular Weight: 322.74800
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2017-10-17 16:04:27
Modify Date: 2024-01-03 15:06:10
PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

Name	4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine
Synonyms	3bgp PIM-1 INHIBITOR 2 benzisoxazole-pyrimidine,2

Description	PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> Pim
Target	PIM1:91 nM (Ki)
References	[1]. Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51(6):1972-5.