Caspase-1 Inhibitor II
Modify Date: 2025-08-26 16:03:36
Caspase-1 Inhibitor II structure
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Common Name | Caspase-1 Inhibitor II | ||
|---|---|---|---|---|
| CAS Number | 178603-78-6 | Molecular Weight | 540.994 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 969.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H33ClN4O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 539.9±34.3 °C | |
Use of Caspase-1 Inhibitor IIAc-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2]. |
| Name | ac-yvad-cmk |
|---|---|
| Synonym | More Synonyms |
| Description | Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-1 |
| In Vitro | Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2]. |
| In Vivo | Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2]. Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 969.1±65.0 °C at 760 mmHg |
| Molecular Formula | C24H33ClN4O8 |
| Molecular Weight | 540.994 |
| Flash Point | 539.9±34.3 °C |
| Exact Mass | 540.198669 |
| PSA | 191.00000 |
| LogP | 1.93 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.554 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|---|
| WGK Germany | 3 |
| RTECS | AY3079566 |
| Ac-YVAD-cmk |
| N-Ac-Tyr-Val-Ala-Asp-CMK |
| AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE |
| AC-YVAD-CHLOROMETHYLKETONE |
| AC-TYR-VAL-ALA-ASP-CH2CL |
| AC-TYR-VAL-ALA-ASP-CMK |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]-L-alaninamide |
| PASE-1 INHIBITOR II |
| ICE INHIBITOR II |
| IL-1BETA CONVERTING ENZYME INHIBITOR II |
| L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]- |
| AC-TYR-ALA-ASP-CHLOROMETHYLKETONE |
| N-Acetyl-L-tyrosyl-L-valyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-alaninamide |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Ac-YVAD-cmk
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: Ac-YVAD-cmk
- Price: $2200.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Nanjing Peptide Biotech Ltd
- China
- Product Name: Ac-Tyr-Val-Ala-Asp-chloromethylketone
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Delivery: 7 Day
- Contact: jom
- Email: chenglong.fan@njpeptide.com
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Price: ￥800/1 mg
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