HIF-1 inhibitor-4

Names

[ Name ]:
HIF-1 inhibitor-4

[Synonym ]:
Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-

Biological Activity

[Description]:

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[In Vitro]

HIF-1 inhibitor-4 (Compound 1) 抑制 HIF-1，IC50 为 560 nM (使用 U251 细胞进行定量，在 VEGF 启动子 (VEGF-PLAP) 的控制下表达 PLAP 报告基因)[1]。

[References]

[1]. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₉IN₂O₂

[ Molecular Weight ]:
422.26013

Related Compounds

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