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Pim-1 Inhibitor 2

Names

[ CAS No. ]:
477845-12-8

[ Name ]:
Pim-1 Inhibitor 2

[Synonym ]:
3bgp
PIM-1 INHIBITOR 2
benzisoxazole-pyrimidine,2

Biological Activity

[Description]:

PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a Ki of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[Target]

PIM1:91 nM (Ki)


[References]

[1]. Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008 Mar 27;51(6):1972-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H11ClN4O

[ Molecular Weight ]:
322.74800

[ Exact Mass ]:
322.06200

[ PSA ]:
77.83000

[ LogP ]:
4.76860

Related Compounds