HIV-1 inhibitor 18A

Names

[ Name ]:
HIV-1 inhibitor 18A

[Synonym ]:
(2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide
MFCD00617448
Hydrazinecarboxamide, N-2,1,3-benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-, (2E)-

Biological Activity

[Description]:

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.

[References]

References 1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52. 2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29. View Related Products by Target HIV

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₁₁N₅O₂S

[ Molecular Weight ]:
313.334

[ Exact Mass ]:
313.063354

[ LogP ]:
3.04

[ Index of Refraction ]:
1.758

Related Compounds

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