[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
Modify Date: 2024-01-12 17:18:52
![[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Structure](https://www.chemsrc.com/caspic/405/149270-28-0.png)
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) structure
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Common Name | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) | ||
|---|---|---|---|---|
| CAS Number | 149270-28-0 | Molecular Weight | 804.97 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H64N8O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3]. |
| Name | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) |
|---|
| Description | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3]. |
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| Related Catalog | |
| Target |
NK2 |
| In Vivo | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (30-100 μg/kg，皮下注射) 增加了小型猪的膀胱和结肠直肠压力峰值[1]。 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (0.3 μg/kg 静脉注射或 100 μg/kg 鼻腔吸入) 也会增加膀胱和结肠直肠压力[1]。 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (10-100 μg/kg，静脉注射，每天四次，连续六天) 在有意识的狗中引起排尿和排便、呕吐和低血压[2]. Animal Model: Anesthetized minipigs[1] Dosage: 30-100 μg/kg Administration: Subcutaneous injection (s.c.) Result: Showed significant, non-linear, dose-dependent increase in peak bladder and colorectal pressures, and was blocked by GR 159897 (HY-107691)(1 mg/kg i.v., 15 min prior to LMN-NKA). Animal Model: Conscious dogs[2] Dosage: 10-100 μg/kg Administration: Intravenous injection (i.v.), four times daily for six consecutive days. Result: Elicited NK2 receptor-mediated micturition defecation and NK1 receptor-mediated emesis and hypotension. |
| References |
[3]. Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019. |
| Molecular Formula | C39H64N8O10 |
|---|---|
| Molecular Weight | 804.97 |