(Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10)

Modify Date: 2024-01-02 08:46:49

(Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10) structure	Common Name	(Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10)
	CAS Number	135306-85-3	Molecular Weight	1081.22000
	Density	1.361 g/cm3	Boiling Point	1555.4ºC at 760 mmHg
	Molecular Formula	C₅₇H₆₈N₁₂O₁₀	Melting Point	N/A
	MSDS	USA	Flash Point	894.5ºC

Use of (Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10)

Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Name	asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2
Synonym	More Synonyms

Description	Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Peptides Research Areas >> Others
Target	Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]
In Vitro	Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
In Vivo	Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
References	[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.

Density	1.361 g/cm3
Boiling Point	1555.4ºC at 760 mmHg
Molecular Formula	C₅₇H₆₈N₁₂O₁₀
Molecular Weight	1081.22000
Flash Point	894.5ºC
Exact Mass	1080.52000
PSA	374.63000
LogP	6.53410
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.672
Storage condition	-20°C
Water Solubility	Insuluble (2.3E-3 g/L) (25 ºC)

MSDS(Chinese)

Hazard Codes	N
RIDADR	NONH for all modes of transport
WGK Germany	3.0

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L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2

NK2 TACHYKININ RECEPT

M.W. 1081.24 C57H68N12O10

(TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10)

Men 10376