neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Modify Date: 2025-08-25 16:36:50

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- structure	Common Name	neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
	CAS Number	126050-12-2	Molecular Weight	1109.238
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₇H₆₈N₁₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively[1][2].

Name	[TYR5,D-TRP6,8,9, ARG10]-NEUROKININ A(4-10)
Synonym	More Synonyms

Description	MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	Tachykinin NK2 Receptor:7.9 (pA2) NK1:5.2 (pA2) NK3:4.9 (pA2)
In Vitro	In competitive radioligand binding assays, MEN 10207 (the IC50 ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor[3].
In Vivo	but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation[1]. Animal Model: Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1] Dosage: 7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL Administration: Intrathecal administration; once Result: Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner.
References	[1]. X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90. [2]. P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5. [3]. A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8.

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₇H₆₈N₁₄O₁₀
Molecular Weight	1109.238
Exact Mass	1108.524292
LogP	3.11
Index of Refraction	1.711

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

5-Tyr-6,8,9-Trp-10-Arg-NKA (4-10)

5-Tyr-6,8,9-Trp-10-Arg-neurokinin A (4-10)

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MEN 10207
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: MEN 10207
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- suppliers

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- price

neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Use of neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.