Neurokinin A(4-10)

Modify Date: 2025-08-25 00:55:47

Use of Neurokinin A(4-10)

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.

Name	neurokinin a (4-10)
Synonym	More Synonyms

Description	Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
Target	NK2 receptor[1]
In Vitro	Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].
References	[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

Density	1.276g/cm3
Boiling Point	1231.2ºC at 760mmHg
Molecular Formula	C₃₄H₅₄N₈O₁₀S
Molecular Weight	766.90500
Flash Point	698.4ºC
Exact Mass	766.36800
PSA	326.54000
LogP	1.25010
Index of Refraction	1.565
InChIKey	YLVSTHFZZCHRCL-UHFFFAOYSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(N)CC(=O)O)C(C)C)C(N)=O

Neurokinin A(4-10) MSDS(Chinese)

ASP-SER-PHE-VAL-GLY-LEU-MET-NH2

DSFVGLM-NH2

L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH2

NKA(4-10)

A-NEUROKININ FRAGMENT 4-10

H-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2

Neurokinin A(4-10)

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