Neurokinin A(4-10)

Names

[ Name ]:
Neurokinin A(4-10)

[Synonym ]:
ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
DSFVGLM-NH2
L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH2
NKA(4-10)
A-NEUROKININ FRAGMENT 4-10
H-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
Neurokinin A(4-10)

Biological Activity

[Description]:

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Peptides

[Target]

NK2 receptor[1]

[In Vitro]

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

[References]

[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.276g/cm3

[ Boiling Point ]:
1231.2ºC at 760mmHg

[ Molecular Formula ]:
C₃₄H₅₄N₈O₁₀S

[ Molecular Weight ]:
766.90500

[ Flash Point ]:
698.4ºC

[ Exact Mass ]:
766.36800

[ PSA ]:
326.54000

[ LogP ]:
1.25010

[ Index of Refraction ]:
1.565

Neurokinin A(4-10)

Names

Biological Activity

Chemical & Physical Properties

MSDS

Click to get detail MSDS

Related Compounds